2024 Sumo chains: polymeric signals

Sumo chains: polymeric signals

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August undefined, 2024

WebPosttranslational modification of proteins by the small ubiquitin-like modifier (SUMO) is a potent regulator of various cellular events. Hundreds of substrates have been identified, … Web10 Jan 2024 · One signaling process initiated by SUMO chains is the SUMO-targeted Ubiquitin ligase (StUbL) pathway. In this evolutionary conserved pathway, poly- (or multi-) …

A high throughput mutagenic analysis of yeast sumo structure …

Web1 Feb 2010 · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" Smith J Web6 Feb 2024 · Author summary The Small ubiquitin-related modifier (SUMO) is a 100 amino acid protein that is attached to other proteins and thereby regulates nearly all essential … the paper studio vinyl iron on

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WebTarget proteins are conjugated to ubiquitin monomers or to ubiquitin polymers that form via all seven internal lysine residues of ubiquitin. The fate of these target proteins is … WebMonomeric and polymeric forms of SUMO and ubiquitin are covalently ... SUMO-Ub chains may also function as signals that affect lysosomal . ... Hybrid suMo-ub chain receptors. … WebSUMO (small ubiquitin-related modifier) shares the ability of ubiquitin to form chains via internal SUMOylation sites. Interestingly, a SUMO-binding site in Ubc9 is important for … shuttle embroidery machine

Decoding the SUMO signal — Discovery - the University of Dundee ...

Chemical Synthesis of diSUMO Photoaffinity Probes for the ...

WebInvestigations into the biological role of polymeric chains have been hampered by the absence of a protocol for the purification of proteins linked to SUMO chains. In this paper, … WebThe SUMO monomers display homogeneous fluorescence spots at the single-molecule level, whereas the mixed SUMO chains exhibit nonuniform fluorescence spots with a wide … shuttle employmentWeb19 Jan 2010 · SUMO chains play roles in replication, in the turnover of SUMO targets by the proteasome and during mitosis and meiosis. Thus signalling via polymers is an exciting … shuttle enchantments

"WebThrough these interactions, SUMO chains exert effects on meiosis and chromatin structure. Recently, additional polySUMO-binding proteins, including Arkadia, FLASH, C5orf25 and … " - Sumo chains: polymeric signals

Sumo chains: polymeric signals

Web7 Nov 2008 · SUMO ligases generally enhance free chain formation and often stimulate the assembly of long polymeric conjugates on suitable substrates in vitro, but at least under … Web7 Nov 2008 · In mammalian cells, the RING finger E3 RNF4 bears four closely spaced SIMs in its N-terminal region (Figure 2A).All of them contribute to SUMO binding, and although …

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Web1 Apr 2024 · Unfortunately, the capture of interactors such as RNF4 and RNF111 using diSUMO-2 pull-down probes proved very difficult (data shown below), mainly because the … WebPost-translational modification by SUMO is a dynamic and reversible process and several SUMO-specific proteases that remove SUMO from substrates have been identified. We …

WebPost-translational modification by small ubiquitin-like modifier (SUMO) has emerged as a global mechanism for the control and integration of a wide variety of biological processes … Web1 Feb 2024 · The SUMO-targeted ubiquitin ligases (STUbLs) RING-finger protein 4 (RNF4) and RNF111 recognize SUMO polymers in a chain-architecture-dependent manner, leading …

Web1 Dec 2009 · Polyubiquitin chains: polymeric protein signals. Curr. Opin. Chem. Biol. 8, 610-616. Potts, P. R. (2009). The Yin and Yang of the MMS21-SMC5/6 SUMO ligase complex in … WebThe small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. …

Web28 Feb 2010 · Interestingly, a SUMO-binding site in Ubc9 is important for SUMO chain synthesis. Similar to ubiquitin-polymer cleavage by USPs (ubiquitin-specific proteases), …

WebOn the contrary, direct detection is possible with mass spectrometry (MS) by the identification of the SUMO–SUMO branched peptide remnant after proteolytic digestion. … shuttle embroidery shuttle emerald coveWeb10 Jan 2024 · One signaling process initiated by SUMO chains is the SUMO-targeted Ubiquitin ligase (StUbL) pathway. In this evolutionary conserved pathway, poly- (or multi-) … shuttle endeavour los angelesWebSUMO chain formation is reversible; SUMO polymers are disassembled by SUMO proteases both in vitro and in vivo. SUMO chains play roles in replication, in the turnover of SUMO … shuttle engine failureWebThe small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. … shuttle emoryWebSUMO chains: polymeric signals Alfred C.O. Vertegaal 46–49 Antiviral activity of resveratrol Michela Campagna and Carmen Rivas 50–53 SUMO and ubiquitin modiﬁcations during … the paper studio vinyl heat settingsWebSmall ubiquitin-like modifiers (SUMOs) regulate virtually all nuclear processes. The fate of the target protein is determined by the architecture of the attached SUMO protein, which … the paper submission