Web1 Dec 2024 · SPOP (Speckle-type POZ Protein) is one of the most frequently mutated genes in primary prostate cancer, suggesting that SPOP may be a potential driver of prostate … WebNumerous studies have determined that SPOP suppresses tumorigenesis in a variety of human malignancies such as prostate, lung, colon, gastric, and liver cancers. However, several studies revealed that SPOP exhibited oncogenic function in kidney cancer, suggesting that SPOP could exert its biological function in a cancer type-specific manner.
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SPOP promotes ATF2 ubiquitination and degradation to suppress …
Webgenetic alterations. SPOP (Speckle-type POZ Protein) is one of the most frequently mutated genes in primary prostate cancer, suggesting that SPOP may be a potential driver of … WebSPOP, an E3 ubiquitin ligase adaptor, can act either as a tumour suppressor or a tumour promoter. In prostate cancer (PCa), it inhibits tumorigenesis by degrading several oncogenic substrates ... Web30 Apr 2024 · Speckle-type pox virus and zinc finger (POZ) protein (SPOP) is a substrate adaptor of cullin 3-based E3 ligase and targets multiple substrates with important … excel separate month day year