Sphk1 cancer
WebSphingosine kinase 1 (SphK1) is a tumor-associated protein overexpressed in numerous types of cancer and is involved in the regulation of resistance to multiple … WebNov 16, 2024 · Sphingosine kinase 1 (SphK1) is a key enzyme with a well-established role in the regulation of sphingolipid metabolism [ 4 ]. SphK1 catalyzes the phosphorylation of sphingosine to produce sphingosine-1-phosphate (S1P), which can act through S1P receptor (S1PR) pathway and intracellular pathway [ 4 ].
Sphk1 cancer
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WebSphingosine kinase 1 (SPHK1) is a lipid kinase that phosphorylates sphingosine to generate S1P. S1P has been proven to be positively correlated with chemotherapy resistance in breast cancer, colorectal carcinoma and non‑small cell lung cancer. However, whether SPHK1 is involved in the development of cisplatin resistance remains to be elucidated. WebBackground: SphK1 is a conserved lipid kinase, which can catalyze formation of tumor promoting factor sphingosine phosphate-1 (S1P). Objective: To investigate effect of SphK1 on proliferation/migration of colon cancer cells and associated mechanisms. Methods: Transcription of SphK1 gene in colon cancer cells was detected. Gene transcription of ...
WebNov 8, 2024 · In the context of cancer, SPHK1 is the main isoform that is functionally associated with the hallmarks of cancer, which has been universally recognized as a key … WebFeb 27, 2014 · The effects of SphK1 inhibition on colon cancer cell viability and the phosphoinositide 3-kinase (PI3K)/Akt cell survival pathway were investigated using a SphK1-selective inhibitor—compound 5c (5c). The cytotoxicity of a novel combination using SphK1 inhibition with the chemotherapeutic drug, 5-fluorouracil (5-FU), was also determined. …
WebAug 15, 2008 · SphK1 的表达在癌症（包括白血病）中上调，并与癌症进展相关。 筛选出的鞘氨醇类似物鉴定为 (2R,3S,4E)-N-methyl-5- (4'-pentylphenyl)-2-aminopent-4-ene-1,3-diol，命名为 SK1-I (BML-258) ，作为 SphK1 的有效、水溶性、同工酶特异性抑制剂。 与 pan-SphK 抑制剂相比，SK1-I 不抑制 SphK2、PKC 或许多其他蛋白激酶。 SK1-I 降低人白血病 … WebAbstract. The role of phospholipid signaling in ovarian cancer is poorly understood. Sphingosine-1-phosphate (S1P) is a bioactive metabolite of sphingosine that has been associated with tumor progression through enhanced cell proliferation and motility.
WebApr 29, 2016 · SphK1 promoted cancer growth via multiple mechanisms, including S1P signaling to cancer cells. Sequestering S1P with a specific S1P monoclonal antibody …
WebNot only has elevated SPHK1 in cancer tissues been implicated in disease progression, but systemic SPHK1 has been implicated in promoting metastasis through a feedback mechanism whereby systemic S1P, signalling through tumour cell S1P 2 receptors, suppresses the expression of the protein breast carcinoma metastasis suppressor 1, … diy wireless dmxWebSep 20, 2024 · SphK1 is translocated from the cytoplasm to the plasma membrane and interacts with calcium-myristoyl switch protein 1 after ERK1/2 phosphorylation/activation in the presence of different agonists (such as TNF, … crash rockets bandWebApr 16, 2009 · Among enzymes that control this metabolism, sphingosine kinase-1 (SphK1), a tumor-associated protein overexpressed in many cancers, favors survival through S1P production, and inhibitors of SphK1 are used in ongoing clinical trials to sensitize epithelial ovarian and prostate cancer cells to various chemotherapeutic drugs. crash rockstar editorWebThe SPHK1-induced autophagy in HPMCs increased the invasive capability of gastric cancer cells, whereas SPHK1 knockdown inhibited autophagy. This was associated with a poor prognosis and recurrence in these patients. SPHK1 is also involved in the production of ceramide, a prominent lipid metabolite that will be discussed in the following section. diy wireless burglar alarm kitsWebOct 15, 2008 · The pharmacologic and RNA silencing inhibition of SphK1 activity prevents the accumulation of HIF-1α and its transcriptional activity in several human cancer cell lineages (prostate, brain, breast, kidney, and lung), suggesting a canonical pathway. diy wireless doorbell cameraWebNov 14, 2024 · SphK1 mainly exists in the cytosol, but SphK2 exists in the nuclei and mitochondria. S1P produced by SphK1 is exported to the extracellular space, where it … crash rocket gameWebMar 3, 2024 · SPHK1 expression was closely correlated with RCC progression-related clinicopathological parameters. Therefore, elevated SPHK1 could effectively diagnose RCC and distinguish RCC with an advanced clinical stage and a high pathological grade. ... Renal cell carcinoma (RCC) is the sixth most frequently diagnosed cancer in male patients and … diy wireless charging circuit