Phenylacetate-coa
WebPhenylalanine was completely oxidized and served as the sole source of cell carbon. Evidence is presented that degradation proceeds via benzoyl-CoA as the central aromatic intermediate; the aromatic ring-reducing enzyme benzoyl-CoA reductase was present in cells grown on phenylalanine. Webphenylacetic acid: [ fen″il-ah-se´tik ] a catabolite of phenylalanine ; it is excessively formed and excreted, sometimes conjugated with glutamine , in phenylketonuria .
Phenylacetate-coa
Did you know?
WebApr 15, 2008 · The phenylacetate-CoA ligase gene ( paaK) was cloned and heterologously expressed in Escherichia coli and the recombinant protein was purified. The enzyme catalyzed phenylacetate + CoA + MgATP → phenylacetyl-CoA + AMP + MgPP i with a V max of 24 μmol/min/mg protein at a temperature optimum of 75°C. WebThe aerobic strategy is illustrated by the metabolism of phenyl-acetate and phenylacetyl-CoA, which are derived froma varietyof substrates such as phenylalanine, lignin-related …
WebDownload alignment. phenylacetate-CoA oxygenase, PaaG subunit. Phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA (PA-CoA) as the second catabolic step in phenylacetic acid (PA) degradation. Although the exact function of this enzyme has not been determined, it has … WebNational Center for Biotechnology Information
WebApr 26, 2011 · Phenylacetate is first activated through the addition of CoA. The phenylacetyl-CoA is then converted to epoxide by a multicomponent monooxygenase. The aromatic … WebJan 15, 2009 · The phl gene, encoding a PCL (phenylacetate-CoA ligase), was cloned in Escherichia coli as a maltose-binding protein fusion and the biochemical properties of …
http://eawag-bbd.ethz.ch/pac/pac_map.html
WebApr 21, 2006 · The acyl-CoA ligand is bound at the protomer-protomer interface with the acyl-thioester moieties inserted into the core of the dimer. The ligand CoA units rest on … click in the cloud loginWebAug 10, 2010 · Although a phenylacetate metabolic gene cluster had been identified, the underlying biochemistry remained largely unknown. Here we elucidate the catabolic pathway functioning in 16% of all... click in the cloud community integrated careWebPhenylacetate-CoA ligase (PA-CoA ligase) catalyzes the first step in aromatic catabolism of phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Often located in a conserved … bmw x series car dealer near lawndaleWebPhenylacetate. Optimal Result: 0 - 0.18 mcg/mg creatinine. Interpret your laboratory results instantly with us. Phenylacetate is produced from bacterial degradation of unabsorbed … bmw x series car dealer near lincolnWebDec 1, 2014 · In addition, transcription of candidate genes for the anaerobic phenylacetate degradation, benzoyl-CoA degradation and glutaryl-CoA degradation pathways was significantly upregulated in microarray and quantitative real-time-PCR studies comparing phenylacetate-grown cells with acetate-grown cells. These results suggested that the … click in the cloud portalWebAug 1, 2008 · Phenylacetate-CoA ligase (E.C. 6.2.1.30), the initial enzyme in the metabolism of phenylacetate, was studied in Thermus thermophilus strain HB27. Enzymatic activity was upregulated during growth ... bmw x series car dealer near hartfordWebJul 1, 2024 · Phenylacetate is converted into phenylacetyl-CoA by phenylacetate-CoA ligase, and this product then undergoes a series of degradative steps through ring hydroxylation, ring opening, and β-oxidation type degradation [122]. The PaaI thioesterases release CoA from phenylacetyl-CoA, as well as mono- and dihydroxylated compounds 4 ... click in the knee