WebThus, the phenolphthiocerol synthase PKS cluster of M. tuberculosis is responsible, in part, for the synthesis of a virulence determinant called phthiocerol dimycocerosate (PDIM). Here, we provide evidence that the PpsE protein, which is part of that cluster, interacts with the type II thioesterase TesA of M. tuberculosis. WebDec 1, 2024 · Phthiocerol dimycocerosates (DIM), glycosylated phenolphthiocerol and acid methanolysates are the three characteristic waxes of M.tb. Dimycocerosates of the phthiocerol detected in the free lipids along with glycosylated phenolphthiocerol, also known as phenolglycolipid (PGL), are two important groups of virulence factors in mycobacterial ...
Analysis of the Phthiocerol Dimycocerosate Locus …
WebPossible conserved polyketide synthase associated protein papa5; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol … WebDec 9, 2005 · Glycosylated p-hydroxybenzoic acid methyl esters and structurally related phenolphthiocerol glycolipids are important virulence factors of Mycobacterium tuberculosis. Although both types of molecules are thought to be derived from p-hydroxybenzoic acid, the origin of this putative biosynthetic precursor in mycobacteria … credit portfolio view模型优缺点
CDC - NIOSH Pocket Guide to Chemical Hazards - Phenol
WebNew members of the phthiocerol and phenolphthiocerol families from Mycobacterium marinum. Gurdyal S. Besra, Anthony I. Mallet, David E. Minnikin and Malin Ridell Abstract. Phthiocerols and phenolphthiocerols from Mycobacterium marinum have erythro, instead of the more usual threo ... WebNIOSH/OSHA. Up to 50 ppm: (APF = 10) Any air-purifying half-mask respirator with organic vapor cartridge (s) in combination with an N95, R95, or P95 filter. The following filters may … WebSome taxa known to possess this pathway include : Mycobacterium marinum, Mycobacterium tuberculosis H37Rv, Mycobacterium tuberculosis variant bovis Expected Taxonomic Range: Mycobacteriaceae, Nocardiaceae Synonyms: PGL biosynthesis; triglycosyl dimycocerosyl phenolphthiocerol biosynthesis credit pool meaning