List of lysosomotropic agents
Web30 okt. 2024 · The concept of lysosomotropic agents significantly changed numerous aspects of cellular biochemistry, biochemical pharmacology, and clinical medicine. In the … Web16 mrt. 2024 · The purpose of these studies was to characterize the cellular impact of lysosomotropic compounds. As shown in Table 1, eight therapeutically and structurally diverse drugs, including chloroquine, fluoxetine, imipramine, dimebon, tamoxifen, chloropromazine, amitriptyline, and verapamil were selected.
List of lysosomotropic agents
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WebSince the beginning of the COVID-19 pandemic, a potential antiviral effect of lysosomotropic agents has been supported by clinical observations in patients receiving CAD-containing treatments. Indeed, several psychiatric hospitals over the world have observed a lower prevalence of symptomatic infections in psychiatric patients, putting … Web4 mei 2024 · Lysosomotropic compounds affect prominent inflammatory messengers, such as IL1B, CCL4, CCL20, and IL6, as well as cathepsin L dependent viral entry (fusion) …
Web6 okt. 2008 · Autophagy, lysosomal changes, and oxidative stress have been associated with a lengthening list of anticancer treatments, and lysosomotropic agents have shown anticancer activity either alone or in combination with other therapeutic agents (Shoemaker and Dagher, 1979; Ohta et al., 1998; Ostenfeld et al., 2005; Amaravadi et al., 2007; … Web22 nov. 2013 · It is well documented that lysosomotropic agents can trigger lysosomal membrane permeabilization [52,53]. We have previously shown that the cell death associated with lysosomotropic compounds can be rescued by Bafilomycin A, which increases lysosomal pH and prevents compound accumulation, further supporting …
Web6 aug. 2024 · Lysosomotropic detergents are well-studied LMP-promoting agents that function by directly disrupting membrane dynamics leading to organelle leakage or by impairing function of lysosomal lipases . Under physiological conditions, LDCD contributes to tissue remodeling during mammary gland involution ( 160 ) and regulates immune cell … WebThe compounds that accumulate in lysosomes are classified as lysosomotropic agents. Roshan Ashoor, Rolla Yafawi, Bart Jessen, Shuyan Lu, 'The Contribution of …
WebAbstract. A sigma-2 receptor ligand siramesine induces lysosomal leakage and cathepsin-dependent death of cancer cells in vitro and displays potent anti-cancer …
WebWith the aim to identify other lysosomotropic drugs with possible inherent antiviral activity, we have applied a set of clear physicochemical, pharmacokinetic and molecular criteria … iplayer malory towers term2Web19 okt. 2024 · Background and Purpose: Drug repositioning is a promising strategy for discovering new therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their antitumor activity because of several epidemiological studies reporting lower cancer incidence in individuals receiving long term drug treatment.Experimental … oratory open dayiplayer megabuildWebLysosomal exocytosis is also perturbed in a variety of lysosomal and lipid storage disorders (reviewed in Samie and Xu, 2014;Settembre and Ballabio, 2014), and lysosomal exocytosis can drive the... iplayer mayfliesWeb1 aug. 2024 · Some lysosomotropic compounds used in experimental work on endolysosomal trafficking and function include the tricyclic antidepressants, imipramine and amitriptyline; the antipsychotic, chlorpromazine; and the selective serotonin re-uptake inhibitor, fluoxetine [50]. oratory organsWebDownload Table LogP and pKa values and molecular structures of the lysosomotropic drugs used in this work from publication: Lysosomal accumulation of anticancer drugs … oratory overwhelmedWeb18 sep. 2014 · Lysosomes are acidic organelles essential for degradation, signalling and cell homoeostasis. In addition, they play a key role in cell death. Permeabilization of the lysosomal membrane and release of hydrolytic enzymes to the cytosol accompanies apoptosis signalling in several systems. The regulatory mechanism of lysosomal stability … oratory peq