WebNov 2, 2024 · 123 generated Cyp19a1 Cre/LoxP conditional KO mice under the control of the GFAP 124 promoter. Specifically, the GFAP-Cre (purchased from Jack son lab) mice were crossed 125 with Cyp19a1 flox/flox mice, which contain LoxP sites flanking exons 10 and 11 of the 126 Cyp19a1 gene. The Cyp19a1 flox/flox (FLOX) mice were created by … WebMar 28, 2024 · Synonym: Amh-mis-Cre, Amhr2cre, Amhr2cre, Amhr2-cre, Amhr-2/Cre. Molecular description: A cassette containing IRES-cre and an FRT-flanked neo cassette was inserted into exon 5 of the endogenous gene. Expression of functional cre recombinase was detected in both male and female gonads and in the Mullerian duct.
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WebThe Cyp19a1-Cre transgenic line was generated by BAC (bacterial artificial chromosome) recombination (Yao et al., 2024). A Lox-STOP-Lox-tdTomato reporter line with a LoxP-flanked STOP was used to express tdTomato in Cre + cells (Ai9, The Jackson Laboratory; Madisen et al., 2010). Homozygous Cyp19a1-Cre mice were crossed with homozygous … WebThe Cyp19a1-Cre transgenic line was generated by BAC (bacterial artificial chromosome) recombination (Yao et al., 2024); its expression pattern faithfully recapitulates endogenous aromatase expression (Yao et al., 2024) and displays no known behavioral deficits in either heterozygous or homozygous animals. marvel political correctness
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WebIn vertebrates, cytochrome P450 aromatase, encoded by cyp19a1, converts androgens to estrogens and plays important roles in gonadal differentiation and development. ... (CRE) of the cyp19a1a promoter was hypermethylated in the ovotestis and testis compared with the ovary. The methylation levels of CpG sites around CRE in the distal region ... Web027038 B6.129S(SJL)- Cyp19a1 tm2.1(cre)Shah /J aro Cre mice express Cre recombinase in portions of the amygdala. They may be useful in applications examining sexually … WebFeb 17, 2012 · Regulatory sequences associated with the human Cytochrome P450 family 19 subfamily A member 1 (Cyp19a1) gene, several mouse genes (Trophoblast specific protein alpha, Tpbpa; Prolactin … marvel poll buzzfeed