WebMar 31, 2024 · The present study evaluated the in vitro and in vivo anticancer effects of Pd 2 Spm compared to the reference metal-based drug cisplatin. Triple-negative breast cancer MDA-MB-231 cells, non-cancerous MCF-12A breast cells and chorioallantoic membrane (CAM) assay were used for antiproliferative, antimigratory and antiangiogenic studies. WebCisplatin (DDP) was reported to improve pathological complete response (pCR) rates in triple-negative breast cancer (TNBC) patients, however, the molecular mechanism still remains largely unknown. Emerging evidence suggested that some chemotherapeutic drugs played anti-tumor effects by inducing cell pyroptosis.
TGF-β-Induced TMEPAI Attenuates the Response of Triple-Negative Breast ...
WebFeb 15, 2024 · A total of 34 patients were treated with adavosertib and cisplatin as first- or second-line therapy for mTNBC. The endpoint was not met, but the objective response rate was 26% and median progression-free survival was 4.9 months. WebTriple-negative breast cancer (TNBC) is the most dangerous subtype with the worst therapeutic prognosis and outcomes due to the absence of receptors for estrogen, progesterone, and HER2. Chemotherapy is the standard treatment for TNBC, and cisplatin is widely used in the clinical management of TNBC [1–3]. Therefore, the loss of … excel change vertical axis labels
Minireview: Basal-Like Breast Cancer: From Molecular Profiles to ...
WebFeb 26, 2024 · Cisplatin is widely used in anticancer chemotherapy in many kinds of cancers, including TNBC. Cisplatin plays an anticancer role mainly via the formation of … WebFeb 28, 2024 · Complex 7 induced apoptosis against two triple-negative breast cancer (TNBC) cell lines, MDA-MB-231, and BT549, with a potency that is, respectively, thirty and three times higher than complex 8 (IC 50 values of 3.6 and 4.0 μM for complex 7 vs. IC 50 values of >100 and 12.78 μM for complex 8 against MDA231 and BT549, respectively). WebApr 10, 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10–20% of all breast cancer cases. Even though platinum … bryce printing